Seaweed growth and secondary metabolite production are significantly influenced by environmental factors, particularly temperature. This study investigated optimal environmental conditions for maximizing Asparagopsis productivity, focusing on temperature and the impact of priming treatments under high-temperature stress, crucial knowledge for cultivation optimization in a changing climate. Initial experiments, varying temperature, salinity, and light intensity revealed that a temperate-origin Asparagopsis strain thrived at 30°C, the highest tested temperature, doubling growth under high light (30 µmol photon m-2s-1) at both 22°C and 30°C. Halogenated compound production peaked at 20°C and 35 ppt salinity. Further experiments explored the effects of priming, exposing cultures to 30°C for one week before returning them to 22°C, then growing them at 30°C and 32°C for three weeks. Primed cultures exhibited 1.5-fold higher growth rates compared to unprimed controls. These findings offer valuable insights for optimizing Asparagopsis cultivation, particularly for commercial production in tropical waters of northern Australia and Southeast Asia.