Marine pollution is a global problem, with the recent United Nations Environmental Protection report (2021) highlighting its far reaching environmental, social, and human-health impacts. Due to oceanic processes, wildlife hotspots often concur with marine pollution. Seabirds are key indicators of this interaction, acting as sentinels as they utilize these pollution hotspots naturally throughout their life history. While there is much research done at the individual level, the impact that non-lethal impacts pollution has at the population level is not yet fully understood. Based within the Galápagos Islands, we used non-invasive methods to identify how pollution impacts the key drivers of population success of the endemic flightless cormorant (Phalacrocorax harrisi). Methods include: Monitoring reproductive behaviour and hatchling success relative to macro-plastic loads found within nesting and foraging habitats; Identifying microplastic levels in guano and the surrounding environment; Identifying persistent organic pollutants in feathers and preen oil; and lastly identifying health implications by monitoring general health, body condition, ectoparasite load, growth rates, and longevity. Early results indicate that only 8% of cormorant nests contain debris, and that they consisted mostly of rope and fibres (72%) and soft plastic bag/fragments (24%), and that both adult and chicks interact directly with these objects.